Sep 14, 2022 · Promethazine Dosage and Administration Administration. Administer orally, rectally, or by deep IM injection. Also administered by IV injection. However, FDA states that deep IM injection is the preferred method for administration of promethazine hydrochloride injection because of risks associated with IV administration (see Warnings Regarding Parenteral Administration under Boxed Warning). Combining opioids and promethazine can cause too much drowsiness. And it could also slow your breathing to a dangerous level. If you need to take them together, your healthcare provider may lower the dosage of your pain medication. You may be surprised that promethazine is available in combination with codeine (an opioid).Aug 1, 2023 · Descriptions. Promethazine and codeine combination is used to relieve cough, runny or stuffy nose, sneezing, or other symptoms caused by allergies or the common cold. Promethazine is an antihistamine. It works by preventing the effects of a substance called histamine, which is produced by the body. Histamine can cause itching, sneezing, runny ... May 22, 2023 · Independently, Codeine and Promethazine are both depressants that largely affect the nervous system, and when they’re combined, the result is intense and euphoric sedation. In larger quantities, lean has been found to induce hallucinations and lucid dreams or nightmares; some artists have claimed it to assist in their creative process. ozanimod. ozanimod and codeine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Avoid or Use Alternate Drug. Because the active metabolite of ozanimod inhibits MAO-B in vitro, there is a potential for serious adverse reactions, including hypertensive crisis. NHS medicines information on codeine – what it's used for, side effects, dosage and who can take it.ozanimod. ozanimod and codeine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Avoid or Use Alternate Drug. Because the active metabolite of ozanimod inhibits MAO-B in vitro, there is a potential for serious adverse reactions, including hypertensive crisis. Aug 4, 2023 · What is Codeine Phosphate-Promethazine HCl? Codeine Phosphate-Promethazine HCl is a combination medicine used to treat cold or allergy symptoms such as runny nose, sneezing, and cough. Codeine Phosphate-Promethazine HCl contains an opioid (narcotic) cough medicine, and may be habit-forming. Codeine Phosphate-Promethazine HCl may also be used ... Promethazine Hydrochloride and Codeine Phosphate Syrup is a prescription medicine used to temporarily treat cough and upper respiratory symptoms that you can have with allergies or a common cold. Promethazine Hydrochloride and Codeine Phosphate Syrup contains 2 medicines, promethazine and codeine. Promethazine is an antihistamine. Codeine and morphine were detected in the milk of both subjects with peak codeine levels in milk occurring 1 hour after the dose. The peak codeine milk level was 455 mcg/L in the first subject and about 450 to 550 mcg/L in the second. The half-life of codeine in breastmilk was 2.5 hours. Morphine milk levels were 16 mcg/L and 9 mcg/L 1 hour ...Codeine and morphine were detected in the milk of both subjects with peak codeine levels in milk occurring 1 hour after the dose. The peak codeine milk level was 455 mcg/L in the first subject and about 450 to 550 mcg/L in the second. The half-life of codeine in breastmilk was 2.5 hours. Morphine milk levels were 16 mcg/L and 9 mcg/L 1 hour ...Codeine is a narcotic pain reliever (analgesic) used to treat mild to moderately severe pain frequently combined with Tylenol or aspirin. Common side effects include itching, rash, stomach pain, constipation, shortness of breath, nausea, lightheadedness, and dizziness. Codeine is a controlled narcotic and it has the potential for abuse. Dependence and addiction can occur with codeine, even at ...Sep 14, 2018 · Codeine is a prescription opioid, which is used as a pain reliever, and promethazine is an antihistamine. Both drugs have sedative effects and can produce feelings of drowsiness, mild euphoria and ... Independently, Codeine and Promethazine are both depressants that largely affect the nervous system, and when they’re combined, the result is intense and euphoric sedation. In larger quantities, lean has been found to induce hallucinations and lucid dreams or nightmares; some artists have claimed it to assist in their creative process.Codeine Information. Codeine is an opioid pain reliever used to treat mild to moderately severe pain. It is also used, usually in combination with other medications, to reduce coughing. Codeine is ...NHS medicines information on codeine – what it's used for, side effects, dosage and who can take it.Phenergan is also found in combination with other medications such as phenylephrine (Prometh Hydrochloride), codeine (Prometh VC), or dextromethorphan (Promethazine DM) What is Phenergan? Phenergan belongs to a group of drugs called phenothiazines. It works by changing the actions of chemicals in your brain. Promethazine also acts as an ...Anecdotal promethazine misuse/abuse reports have been confirmed by European Monitoring Agency data. Promethazine misuse/abuse appears to be an alarming issue, being associated with drug-related fatalities. Thus, healthcare professionals should be warned about a possible misuse of promethazine and be …after a dosage increase. if you are older. if you have an existing lung problem. The side effects of codeine are similar to those of other opioids, and include: constipation. headache or dizziness. fatigue or drowsiness (especially soon after a dose) loss of appetite, nausea and vomiting. Always take medicines exactly as prescribed your doctor.Promethazine with Codeine Oral Solution is a combination of codeine, an opioid agonist; and promethazine, a phenothiazine, indicated for the temporary relief of cough and upper respiratory symptoms associated with allergy or the common cold in patients 18 years of age and older.Lean, also known as purple drank, purp, sizzurp, syrup, wock or oil, and several other names, is a recreational drug beverage, prepared by mixing prescription strength cough or cold syrup containing codeine and promethazine with a soft drink. The beverage originated in Houston and is popular in hip hop culture, especially within the Southern ...Promethazine with codeine syrup is indicated for the temporary relief of coughs and upper respiratory symptoms associated with allergy or the common cold. CONTRAINDICATIONS. The combination of promethazine hydrochloride and codeine phosphate is contraindicated in pediatric patients less than 6 years of age, because the combination may cause ...NHS medicines information on codeine – what it's used for, side effects, dosage and who can take it. Generic Name (S): codeine-guaifenesin. Warnings: This medication has a risk for abuse and addiction, which can lead to overdose and death. This medication may also cause severe, possibly fatal ...Dec 12, 2022 · For all patients taking this drug: This drug has an opioid drug in it. Opioid drugs can put you at risk for addiction, abuse, and misuse. Misuse or abuse of this drug can lead to overdose and death. If you have questions, talk with your doctor. This drug may cause very bad and sometimes deadly breathing problems. In the early 1990s, several studies reported the misuse of codeine and promethazine hydrochloride cough syrup. Since then, the combination of this pharmaceutical, together with sprite or alcohol, known on the streets as "purple drank" or "lean", has become a popular drug among rap singers who promot …codeine/promethazine systemic. Drug class: upper respiratory combinations. Codeine/promethazine systemic is used in the treatment of: Cough; codeine/pseudoephedrine systemic. Brand names: Cycofed, Nucodine, Codar D, Nucofed, EndaCof-DC Drug class: upper respiratory combinations. Codeine/pseudoephedrine systemic is used in the treatment of: Codeine and promethazine es una medicina combinada se usa para el tratamiento de los síntomas del resfrío o alergias como nariz mocosa, estornudos, y tos. Codeine and promethazine contiene una medicina opioide (narcótico) para la tos, y puede crear hábito. . Codeine and promethazine puede también usarse para fines no...Promethazine Hydrochloride and Codeine Phosphate Syrup is a prescription medicine used to temporarily treat cough and upper respiratory symptoms that you can have with allergies or a common cold. Promethazine Hydrochloride and Codeine Phosphate Syrup contains 2 medicines, promethazine and codeine. Promethazine is an antihistamine.Codeine is a drug in some prescription pain medicines. It is in the class of drugs known as opioids, which refers to any synthetic, semisynthetic, or natural drug that has morphine-like properties. Codeine overdose occurs when someone takes more than the normal or recommended amount of this medicine. This can be by accident or on purpose. Tussionex doesn’t belong in the “colored” syrups conversation. Codeine and euphoria don’t belong in the same sentence. It’s the promethazine and codeine combo that gets you “high”. Hydrocodone (especially in the tussionex time release form) isn’t even in the same class as codeine. Tuss is by far the best cough syrup ever madeAug 11, 2023 · Using promethazine, phenylephrine, and codeine for a long time during pregnancy may lead to withdrawal in the newborn baby. This can be life-threatening. Talk with the doctor. How is this medicine (Promethazine, Phenylephrine, and Codeine) best taken? Use promethazine, phenylephrine, and codeine as ordered by your doctor. Phenergan is also found in combination with other medications such as phenylephrine (Prometh Hydrochloride), codeine (Prometh VC), or dextromethorphan (Promethazine DM) What is Phenergan? Phenergan belongs to a group of drugs called phenothiazines. It works by changing the actions of chemicals in your brain. Promethazine also acts as an ...Sep 20, 2012 · Codeine is used to relieve mild to moderately severe pain, and it belongs to the drug class of opioid analgesics. Codeine has also been prescribed to prevent coughing, though the antitussive administration is most often in liquid formulations and in conjunction with other medications. ( 1, 2) The hepatic CYP2D6 enzyme metabolizes a quarter of ... The codeine in Promethazine VC with Codeine can cause newborns to experience withdrawal syndrome, which is life-threatening for infants. Withdrawal syndrome is a condition that develops when Promethazine VC with Codeine crosses through the placenta and causes the unborn baby to become dependent on the medication.Promethazine HCl and Codeine Phosphate Oral Solution exposes patients and other users to the risks of opioid addiction, abuse, and misuse, which can lead to overdose and death. Reserve Promethazine HCl and Codeine Phosphate Oral Solution for use in adult patients for whom theGeneric name: promethazine hydrochloride and codeine phosphate Dosage form: oral solution Drug class: Upper respiratory combinations Medically reviewed by Drugs.com. Last updated on Jan 1, 2022. On This Page Indications and Usage Dosage and Administration Dosage Forms and Strengths Contraindications Warnings and PrecautionsAug 11, 2023 · Using promethazine, phenylephrine, and codeine for a long time during pregnancy may lead to withdrawal in the newborn baby. This can be life-threatening. Talk with the doctor. How is this medicine (Promethazine, Phenylephrine, and Codeine) best taken? Use promethazine, phenylephrine, and codeine as ordered by your doctor. Pediatric. Use of Promethazine VC with codeine oral liquid in children and Promethazine, phenylephrine, and codeine oral solution in children younger than 12 years of age is not recommended. It should not be used to relieve pain after surgery to remove tonsils or adenoids in any children. Severe breathing problems and deaths have been reported ...Feb 1, 2023 · Acetaminophen/codeine oral solution. Each 5 mL of acetaminophen/codeine solution contains 12 mg of codeine and 120 mg of acetaminophen. The typical dose is 15 mL by mouth every 4 hours as needed. Do not take more than 3,000 mg to 4,000 mg of acetaminophen within a 24-hour period. NHS medicines information on codeine – what it's used for, side effects, dosage and who can take it.of codeine due to a CYP2D6 polymorphism. Promethazine HCl and Codeine Phosphate Oral Solution is contraindicated in children younger than 12 years of age and in children younger than 18 years of age following tonsillectomy and/or adenoidectomy (see CONTRAINDICATIONS). Avoid the use of Promethazine HCl and Codeine PhosphatePhenergan with Codeine (promethazine and codeine) is a combination of an antihistamine, sedative, anti-nausea drug, cough suppressant, pain reliever, and cough suppressant used to treat common cold symptoms and cough. Common side effects of Phenergan with Codeine include dizziness, restlessness, inability to sleep, palpitations, and changes in muscle tone and more. Withdrawal symptoms may ... of codeine due to a CYP2D6 polymorphism. Promethazine HCl and Codeine Phosphate Oral Solution is contraindicated in children younger than 12 years of age and in children younger than 18 years of age following tonsillectomy and/or adenoidectomy (see CONTRAINDICATIONS). Avoid the use of Promethazine HCl and Codeine PhosphateAug 29, 2023 · Codeine cough suppressants like promethazine/codeine should only be an option for short-term use — and only in adults. This type of cough syrup is available by prescription. However, it is a controlled substance and habit-forming. Best cough medicine for kids 5.1 Addiction, Abuse, and Misuse. Promethazine with Codeine Oral Solution contains codeine, a Schedule V controlled substance. As an opioid, Promethazine with Codeine Oral Solution exposes users to the risks of addiction, abuse, and misuse [see DRUG ABUSE AND DEPENDENCE (9)], which can lead to overdose and death [seeOVERDOSAGE (10)].Long-term use of opioid medication may affect fertility (ability to have children) in men or women. It is not known whether opioid effects on fertility are permanent. Common side effects include ...Codeine is a drug in some prescription pain medicines. It is in the class of drugs known as opioids, which refers to any synthetic, semisynthetic, or natural drug that has morphine-like properties. Codeine overdose occurs when someone takes more than the normal or recommended amount of this medicine. This can be by accident or on purpose. May 5, 2020 · Promethazine with Codeine Oral Solution is a combination of codeine, an opioid agonist; and promethazine, a phenothiazine, indicated for the temporary relief of cough and upper respiratory symptoms associated with allergy or the common cold in patients 18 years of age and older. Promethazine HCl and Codeine Phosphate Oral Solution exposes patients and other users to the risks of opioid addiction, abuse, and misuse, which can lead to overdose and death. Reserve Promethazine HCl and Codeine Phosphate Oral Solution for use in adult patients for whom theMar 24, 2023 · If you are 65 or older, use promethazine and codeine with care. You could have more side effects. The chance of very bad side effects may be higher in children. This may be more likely to happen in children who have breathing problems. Deadly breathing problems have happened with the use of codeine in some children. Codeine belongs to the group of medicines called narcotic analgesics (pain medicines). It acts on the central nervous system (CNS) to relieve pain. Phenylephrine is a decongestant. It works by narrowing the blood vessels and leads to the clearing of nasal congestion. Promethazine is an antihistamine.Generic name: codeine / promethazine systemic Drug class: upper respiratory combinations. For consumers: dosage, interactions, side effects. For professionals: Prescribing Information. Expand current row for information about Hycodan Hycodan: 8.5 Physical effects. Codeine taken at high doses could produce the following effects that can last 3-5 hours: drowsiness. headaches. slowed breathing. nausea and vomiting. smaller (constricted) pupils. feeling heavy in the arms and legs. severe itching or warm/hot sensation on the skin.Schedule 5 (V) Drugs. The drug has a low potential for abuse relative to the drugs in schedule 4. The drug has a currently accepted medical use in treatment in the United States.Oct 9, 2012 · -Codeine (an opiate that treats pain and coughs) -Hydrocodone (an opiate used to treat moderate to severe pain) -Phenacetin (an analgesic that's not used much anymore) Promethazine is an antihistamine that relieves watery eyes, itchy eyes /nose/throat, runny nose, and sneezing. Codeine is an opioid cough suppressant ( antitussive) that affects a certain part...Generic Name (S): codeine sulfate. Codeine has a risk for abuse and addiction, which can lead to overdose and death. Codeine may also cause severe, possibly fatal, breathing problems. To lower ...Aug 27, 2009 · Each 5 mL (one teaspoonful), for oral administration contains: Promethazine hydrochloride 6.25 mg; codeine phosphate 10 mg. Alcohol 7%. Inactive Ingredients: Ascorbic acid, citric acid, FD&C ... Codeine: Narcotic analgesics, including codeine, exert their primary effects on the central nervous system and gastrointestinal tract. The analgesic ... If you are 65 or older, use promethazine and codeine with care. You could have more side effects. The chance of very bad side effects may be higher in children. This may be more likely to happen in children who have breathing problems. Deadly breathing problems have happened with the use of codeine in some children.Jan 29, 2020 · Lean is a very sweet drink that blends soda with cough syrup containing codeine. Some formulas also add candy or sweetening syrup. Users may also mix in promethazine, which is an antihistamine ... Dec 12, 2022 · For all patients taking this drug: This drug has an opioid drug in it. Opioid drugs can put you at risk for addiction, abuse, and misuse. Misuse or abuse of this drug can lead to overdose and death. If you have questions, talk with your doctor. This drug may cause very bad and sometimes deadly breathing problems. codeine. Used for Pain. Codeine is an opioid pain medication that's taken by mouth and used to treat mild-to-moderate pain. Common side effects of codeine include constipation, itching, sleepiness, and dizziness. It's typically not a first-choice pain medication because it can lead to more serious harm, such as slowed breathing and addiction.Combining opioids and promethazine can cause too much drowsiness. And it could also slow your breathing to a dangerous level. If you need to take them together, your healthcare provider may lower the dosage of your pain medication. You may be surprised that promethazine is available in combination with codeine (an opioid).Mar 24, 2023 · If you are 65 or older, use promethazine and codeine with care. You could have more side effects. The chance of very bad side effects may be higher in children. This may be more likely to happen in children who have breathing problems. Deadly breathing problems have happened with the use of codeine in some children. The codeine in Promethazine VC with Codeine can cause newborns to experience withdrawal syndrome, which is life-threatening for infants. Withdrawal syndrome is a condition that develops when Promethazine VC with Codeine crosses through the placenta and causes the unborn baby to become dependent on the medication.Sep 14, 2022 · Promethazine Dosage and Administration Administration. Administer orally, rectally, or by deep IM injection. Also administered by IV injection. However, FDA states that deep IM injection is the preferred method for administration of promethazine hydrochloride injection because of risks associated with IV administration (see Warnings Regarding Parenteral Administration under Boxed Warning). Oct 10, 2022 · Initial dose: 15 to 60 mg orally up to every 4 hours as needed. Maximum dose: 360 mg in 24 hours. Comments: Initial doses should be individualized taking into account severity of pain, response, prior analgesic treatment experience, and risk factors for addiction, abuse, and misuse. Doses higher than 60 mg have not been shown to improve pain ... Generic Name (S): codeine-guaifenesin. Warnings: This medication has a risk for abuse and addiction, which can lead to overdose and death. This medication may also cause severe, possibly fatal ...Jan 29, 2020 · Lean is a very sweet drink that blends soda with cough syrup containing codeine. Some formulas also add candy or sweetening syrup. Users may also mix in promethazine, which is an antihistamine ... Dec 13, 2022 · severe nervous system reaction--very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, feeling like you might pass out. Side effects such as confusion and severe drowsiness may be more likely in older adults. Common promethazine side effects may include: drowsiness, dizziness; ringing in your ears; Jan 27, 2023 · Promethazine VC with Codeine Oral Solution is a combination of codeine, an opioid agonist; promethazine, a phenothiazine; and phenylephrine, an alpha-1 adrenergic receptor agonist, indicated for the temporary relief of cough and upper respiratory symptoms, including nasal congestion, associated with allergy or the common cold in patients 18 years of age and older. Like other opioids, codeine can be toxic in large amounts. Symptoms of an opioid overdose include: bluish fingernails and lips. confusion. breathing problems, such as slow and labored breathing ...Aug 4, 2023 · What is Codeine Phosphate-Promethazine HCl? Codeine Phosphate-Promethazine HCl is a combination medicine used to treat cold or allergy symptoms such as runny nose, sneezing, and cough. Codeine Phosphate-Promethazine HCl contains an opioid (narcotic) cough medicine, and may be habit-forming. Codeine Phosphate-Promethazine HCl may also be used ... Pediatric. Use of Promethazine VC with codeine oral liquid in children and Promethazine, phenylephrine, and codeine oral solution in children younger than 12 years of age is not recommended. It should not be used to relieve pain after surgery to remove tonsils or adenoids in any children. Severe breathing problems and deaths have been reported ...Promethazine. Codeine is an effective pain reliever; however, it is addictive, may cause constipation, and its pain-relieving effects vary markedly between individuals. Codeine should only be used for pain relief... more. Promethazine may be used to relieve allergy symptoms and nausea. Sedation is the main side effect and it may interact with ... See full list on drugs.com Cough and Cold Medicines • May 2014 • Page 2 ! Drinking!promethazine(codeinecough syrup!mixed!with!soda!(a!combination! calledsyrup,sizzurp,purpledrank,barre,In the early 1990s, several studies reported the misuse of codeine and promethazine hydrochloride cough syrup. Since then, the combination of this pharmaceutical, together with sprite or alcohol, known on the streets as "purple drank" or "lean", has become a popular drug among rap singers who promot …Codeine (3-methylmorphine) is an alkaloid prepared from the methylation of morphine derived from poppy seeds ( Papaver somniferum) [ 1 ]. It is used to manage mild to moderate pain, including chronic cancer pain, and has antitussive, antistress, and antidiarrheal properties [ 2, 3, 4 ]. In the body, a small amount of codeine is metabolized to ...Hycofenix, Rezira (hydrocodone, pseudoephedrine, guaifenesin) Tussionex, Pennkinetic, Vituz (hydrocodone, chlorpheniramine, pseudoephedrine) Generic combinations of hydrocodone and homatropine. Giving prescription cough medicines to kids or teens is dangerous. They can slow their breathing to dangerous levels and can even be fatal.Promethazine. Codeine is an effective pain reliever; however, it is addictive, may cause constipation, and its pain-relieving effects vary markedly between individuals. Codeine should only be used for pain relief... more. Promethazine may be used to relieve allergy symptoms and nausea. Sedation is the main side effect and it may interact with ... Codeine belongs to the group of medicines called narcotic analgesics (pain medicines). It acts on the central nervous system (CNS) to relieve pain. Phenylephrine is a decongestant. It works by narrowing the blood vessels and leads to the clearing of nasal congestion. Promethazine is an antihistamine.
In the early 1990s, several studies reported the misuse of codeine and promethazine hydrochloride cough syrup. Since then, the combination of this pharmaceutical, together with sprite or alcohol, known on the streets as "purple drank" or "lean", has become a popular drug among rap singers who promot … . Annepercent27s precious yorkies
Aug 4, 2023 · Promethazine 6.25 mg/ Codeine 10 mg per 5 mL: Average effective dose: 5 mL orally every 4 to 6 hours as needed. Maximum dose: 30 mL (promethazine 37.5 mg; codeine: 60 mg) in 24 hours. Comments: Liquid preparations should be measured with an accurate milliliter measuring device. Uses: Temporary relief of coughs and upper respiratory symptoms ... NHS medicines information on codeine – what it's used for, side effects, dosage and who can take it.Oct 10, 2022 · Initial dose: 15 to 60 mg orally up to every 4 hours as needed. Maximum dose: 360 mg in 24 hours. Comments: Initial doses should be individualized taking into account severity of pain, response, prior analgesic treatment experience, and risk factors for addiction, abuse, and misuse. Doses higher than 60 mg have not been shown to improve pain ... codeine/promethazine systemic. Drug class: upper respiratory combinations. Codeine/promethazine systemic is used in the treatment of: Cough; codeine/pseudoephedrine systemic. Brand names: Cycofed, Nucodine, Codar D, Nucofed, EndaCof-DC Drug class: upper respiratory combinations. Codeine/pseudoephedrine systemic is used in the treatment of:Dec 13, 2022 · severe nervous system reaction--very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, feeling like you might pass out. Side effects such as confusion and severe drowsiness may be more likely in older adults. Common promethazine side effects may include: drowsiness, dizziness; ringing in your ears; after a dosage increase. if you are older. if you have an existing lung problem. The side effects of codeine are similar to those of other opioids, and include: constipation. headache or dizziness. fatigue or drowsiness (especially soon after a dose) loss of appetite, nausea and vomiting. Always take medicines exactly as prescribed your doctor.See full list on drugs.com Codeine, an opioid analgesic, was originally approved in the US in 1950 and is a drug used to decrease pain by increasing the threshold for pain without impairing consciousness or altering other sensory functions. Opiates such as codeine are derived from the poppy plant, Papaver somniferum (Papaveraceae). Codeine is utilized as a central ...a liquid that you swallow – this contains 25mg of codeine in a 5ml spoonful. The usual dose of codeine is 15mg to 60mg. adults – one or two 30mg tablets, taken every 4 hours, up to a maximum of 8 tablets (240mg) in 24 hours. children (aged 12 to 17 years) – one or two 30mg tablets (or one or two 5ml spoonfuls of liquid), taken every 6 hours.Promethazine HCl and Codeine Phosphate Oral Solution exposes patients and other users to the risks of opioid addiction, abuse, and misuse, which can lead to overdose and death. Reserve Promethazine HCl and Codeine Phosphate Oral Solution for use in adult patients for whom theCommon codeine side effects include: feeling dizzy or drowsy; nausea, vomiting, stomach pain; constipation; sweating; or. mild itching or rash. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.Jan 27, 2023 · Promethazine VC with Codeine Oral Solution is a combination of codeine, an opioid agonist; promethazine, a phenothiazine; and phenylephrine, an alpha-1 adrenergic receptor agonist, indicated for the temporary relief of cough and upper respiratory symptoms, including nasal congestion, associated with allergy or the common cold in patients 18 years of age and older. 5.1 Addiction, Abuse, and Misuse. Promethazine with Codeine Oral Solution contains codeine, a Schedule V controlled substance. As an opioid, Promethazine with Codeine Oral Solution exposes users to the risks of addiction, abuse, and misuse [see DRUG ABUSE AND DEPENDENCE (9)], which can lead to overdose and death [seeOVERDOSAGE (10)]..
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